Evidence Across the Vascular System — Acute to Chronic
PhysioSense has been evaluated across multiple acute care cohorts and chronic disease populations, consistently demonstrating that
non-invasive waveform-derived physiological features correlate with clinically meaningful changes —
often well before conventional vital signs reflect them.
Sepsis & SIRS
Early detection
Vascular phenotype signatures consistently aligned with zero-hour SIRS onset were detectable well before clinical confirmation. Distinct physiological profiles separated stable, deteriorating, survivor, and non-survivor cohorts — without reliance on lab values.
↑ Research showed separation hours before clinical onset
Hemorrhage & Hypovolemia
Pre-symptomatic detection
Arterial compliance changes were detected before any heart-rate or blood-pressure response in controlled physiological challenge models. Findings replicated in real-world ICU validation, with distinct waveform signatures separating hemorrhagic from non-hemorrhagic states.
↑ Detects before hemodynamic instability
Traumatic Brain Injury
Non-invasive ICP surrogate
Peripheral PPG-derived signatures were associated with intracranial physiological events across the critical 48–72 hour cerebral edema window. Distinct “spiker” vs. “flatliner” phenotypes with diverging outcomes identified non-invasively.
↑ PPG tracked TBI phenotypes
Shock — Multi-Type
Trajectory differentiation
Survivor and non-survivor vascular trajectories exhibited distinct patterns across hemorrhagic, septic, and cardiogenic shock types. State-space trajectories clearly differentiated outcome groups in ways that aggregate vital signs could not — enabling earlier clinical decision support.
↑ Survivor/non-survivor separation in state-space
Burns
Phase transition detection
Vasoconstricted early burn shock and late distributive burn phases produce physiologically distinct state-space trajectories. Vascular phenotyping mapped burn-phase identification from waveform alone — with direct relevance for fluid management timing and prognostication.
↑ Burn phase identified from PPG alone
Medication Response Tracking
Real-time drug footprinting
Waveform-derived indices allow for the visualization of distinct vasodilatory
and vasoconstrictive signatures, alongside broader shifts in vascular properties.
This provides a method for tracking physiological trends following
medication administration without requiring additional instrumentation.
Extending into Chronic Disease, Aging, and Longitudinal Monitoring
Beyond acute care, PhysioSense has research addressing dementia and cognitive decline, cardiopulmonary deterioration, CHF, CKD, stroke, diabetes, and related metabolic and neurovascular physiology—creating opportunities at the intersection of longitudinal physiological monitoring, early risk identification, and translational health applications.
Regulatory Status: PhysioSense technology is currently for Research Use Only (RUO).
The clinical findings and physiological “signatures” described above are results from investigational studies
and have not been cleared by the FDA for diagnostic or therapeutic use.
